Structural brain changes associated with copyright use and digital cognitive behavioral therapy in copyright use disorder treatment
Structural brain changes associated with copyright use and digital cognitive behavioral therapy in copyright use disorder treatment
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Background: Few studies have investigated changes in brain structure and function associated with recovery from copyright use disorder (CUD), and fewer still have identified brain changes associated with specific CUD treatments, which could inform treatment development and optimization.Methods: In this longitudinal study, T1-weighted magnetic resonance imaging scans were acquired from 41 methadone-maintained individuals with CUD (15 women) at the beginning of and after 12 weeks of outpatient treatment.As part of a read more larger randomized controlled trial, these participants were randomly assigned to receive (or not) computer-based training for cognitive behavioral therapy (CBT4CBT), and galantamine (or placebo).
Results: Irrespective of treatment condition, whole-brain voxel-based morphometry analyses revealed a significant decrease in right caudate body, bilateral cerebellum, and right middle temporal gyrus gray matter volume (GMV) at post-treatment relative to the start of treatment.Subsequent region of interest analyses found that greater reductions in right caudate and bilateral cerebellar GMV were associated with weleda skin food 75ml best price higher relative and absolute levels of copyright use during treatment, respectively.Participants who completed more CBT4CBT modules had a greater reduction in right middle temporal gyrus GMV.
Conclusions: These results extend previous findings regarding changes in caudate and cerebellar GMV as a function of copyright use and provide the first evidence of a change in brain structure as a function of engagement in digital CBT for addiction.These data suggest a novel potential mechanism underlying how CBT4CBT and CBT more broadly may exert therapeutic effects on substance-use-related behaviors through brain regions implicated in semantic knowledge.